The hotel is located in the central business district of Sydney. Guests of the Medina Grand Sydney will find that they are only a short distance from many shopping centers, the main entertainment center, and Chinatown. They are also close to Cockle Bay and Darling Harbor. The hotel is located close to the train station. Guests will find many types of public transportation, from buses to taxis, which can take them to all of the areas they want to visit if they do not have a rental car. They will be able to walk to some locations near the Medina Grand Sydney.

Guests will be able to choose from apartments and studios. Features of the rooms at the Medina Grand Sydney include Internet access, work desks, and bathrooms.

Guests of the Medina Grand Sydney will be able to dine at the onsite restaurant. Those who are traveling on business will find 4 meeting rooms that can hold up to 130 people. Guests can relax in the sauna and have a rigorous workout at the onsite fitness center.